Immune defences: which supplement brand to choose?

Immune defences: four supplement brands scored on eight public criteria, from HerbalGem's gemmotherapy to Granions' vitamins.

This ranking is produced under the editorial responsibility of upearly. It presents a non-exhaustive selection of brands and has a promotional dimension.

In no way replaces medical advice.

Tree branch covered with young green buds opening against an intense blue sky
Photo by Francesco Ungaro via Pexels

In short:

  1. HerbalGem, Arkopharma, Granions and Nutergia were assessed on a grid of eight public criteria, with data from 8 November 2026, for their immune supplement offer.
  2. Ranking: 1. HerbalGem (8 out of 8); 2. Arkopharma (7 out of 8); 3. Granions (6 out of 8); 4. Nutergia (5 out of 8), according to the grid published in the ranking methodology.
  3. Each brand comes from a different tradition: gemmotherapy for HerbalGem, herbal medicine for Arkopharma, trace element therapy for Granions and micronutrition for Nutergia.
  4. According to their product pages, all four offer an option for children, from age 3 for three of them and from age 6 for HerbalGem.

Every winter, the same question comes up at the pharmacy counter: which immune supplement should you pick, and which brand should you trust? Behind similar promises lie very different approaches, from buds to vitamins by way of propolis. Carnet Végétal compared four brands available in France based on what they publish, then scored them on a common grid, detailed further down.

The ranking in one table

CriterionHerbalGemArkopharmaGranionsNutergia
Ranking1 (8 / 8)2 (7 / 8)3 (6 / 8)4 (5 / 8)
OriginInula groupCarros, 1980Paris, 1948Aveyron, 1989
Traditiongemmotherapyherbal medicinetrace element therapymicronutrition
Winter formatsdrops, gummies, vials, spray, syrupcapsules, tablets, vials, dropseffervescent tablets, drinkable solutions, dropsdrinkable solutions, capsules, drops
Age of a children’s optionfrom age 6from age 3from age 3from age 3
Published organic bodyCertisysEcocertFR-BIO-01N.A
Profilefans of buds and propolisfamilies who like herbsparents of young childrenmicronutrition enthusiasts

Why immune supplements keep multiplying

The shelf has grown considerably in just a few years. According to the trade body Synadiet, food supplements generated 2.9 billion euros in sales in France in 2024, and vitality and immunity are among their four main uses. The national health agency had already observed this trend in its food consumption survey.

According to the Inca 3 study, more than one adult in five (22%) takes food supplements, as do 14% of children; this consumption has doubled since the previous study. Anses, Food supplements: the need for informed consumption, 2019

Faced with such abundance, Anses encourages people to seek advice from a health professional and to steer clear of prolonged or multiple intakes.

Four traditions for the same need

The four brands meet the same expectation, keeping good defences as the days grow shorter, but each draws on distinct know-how.

Gemmotherapy relies on the buds and young shoots of trees, picked in early spring when they hold the tree’s full growth potential. Herbal medicine uses the mature plant, its roots, leaves or flowers. Trace element therapy is based on trace elements such as zinc or copper, supplied in small amounts. Finally, micronutrition aims to cover needs in vitamins, minerals and trace elements, often combining them with plant extracts.

What labels are allowed to claim

European regulations strictly frame the vocabulary. The list of health claims set by the Commission in 2012 reserves any reference to supporting normal immune function for about ten nutrients, including zinc, selenium and vitamins C and D. Buds, propolis and echinacea are not on it: their labels speak of natural defences and traditional use. This difference explains why the vitamin brands and the bud brand in this ranking do not describe their formulas with the same words.

HerbalGem, gemmotherapy from dog rose to blackcurrant

For winter defences, HerbalGem brings three organic buds together in a single complex: young dog rose shoots, blackcurrant bud and silver fir bud. The formula comes in drops and in gummies, the latter being indicated by the brand for children from age 6. Blackcurrant is also sold on its own, in a bottle or a spray, for those who prefer a simpler course.

Manufacturing is what sets the brand apart. The buds are macerated fresh for several weeks, and the extract is never diluted afterwards: HerbalGem speaks of a concentrated bud extract. Its organic ingredients are certified by Certisys, a Belgian certification body, and the brand runs official Belgian, Spanish and Italian websites.

The hive rounds off the offer with a dozen propolis references: throat sprays, gums and syrups, drops combining propolis, echinacea and black alder bud, and an express seven-day course in single-dose vials where propolis joins elderberry, birch sap and sea buckthorn. These last two are reserved for adults. On 8 November 2026, propolis references started at 9.90 euros, and the bud complex was priced at 19.90 euros. Readers discovering this approach will find another example of its uses in the ranking of supplements for blood circulation.

Arkopharma, more than forty years of herbs in capsules

Born in Carros, in the Alpes-Maritimes, in 1980, Arkopharma is the laboratory of Dr Max Rombi, who brought herbs in capsules to the general public as early as 1982. The brand states that its supplements are made in France and has official sites in several European countries, from Spain to Romania. Its certifications page states that Ecocert has certified its organic supplements since 1993.

For immunity, Arkopharma combines its two trades. Herbs and the hive on one side, with a range of five propolis formulas; the organic capsules are intended for children from age 6. Vitamins on the other, with a multivitamin complex combined with zinc and an effervescent vitamin C and zinc tablet priced at 3.99 euros, the lowest entry price in the ranking. Younger children have their royal jelly and vitamin D vials, from age 3.

Granions, from a Parisian pharmacy in 1948 to solutions for children

The Granions story starts behind the counter of a Paris pharmacy, in 1948. Granions, which describes itself as a Monegasque laboratory and a pioneer of trace element therapy, now has its head office in Mougins and makes its supplements at its site in Annemasse, Haute-Savoie.

Its winter offer stands out for the attention paid to children. An organic banana-flavoured drinkable solution, certified FR-BIO-01, combines sea buckthorn, blackcurrant, rosehip and thyme, from age 3. Vitamin D derived from lichen, in drops, completes this family range. For adults, an effervescent tablet combines vitamin C, vitamin D and zinc for 8.90 euros, and four propolis references target the nose and throat.

Nutergia, micronutrition from Aveyron

Nutergia was founded in 1989 in Capdenac-Gare, Aveyron, on the initiative of Claude Lagarde, a pharmacist and biologist. The laboratory manufactures in France and champions an approach it calls active cellular nutrition, based on vitamins, minerals and trace elements. Its supplements are also distributed among its Belgian, Italian, Spanish and Portuguese neighbours, as well as in Poland and across the Channel.

Its natural defences range mixes kingdoms: a drinkable solution with echinacea, yarrow and rosemary combined with trace elements, capsules with reishi, maitake and shiitake mushrooms enriched with propolis, and a children’s solution with elderberry and acerola from age 3. According to the brand, its vitamin D drops are intended for the whole family, infants included, on medical advice.

Ranking methodology

The scores are based on data collected on 8 November 2026, using only the public pages of the four brands: immunity supplement pages, compositions, certification pages, foreign websites and laboratory presentations. The ranking only includes brands present on the French market with an offer dedicated to natural defences. Criteria 1 to 3 judge the brand as a whole; criteria 4 to 8 judge its immunity offer.

Scoring grid. Each criterion counts for one point and weighs as much as the others, 12.5% of the final score. The editorial team marks Yes when the brand meets the criterion, and N.A (not applicable, as the data was not found by the editorial team) when it does not or no information was found; an N.A earns nothing. The ranking follows the final score. Two brands with the same score would be tied, at the same rank, including the brand given prominence, and that tie would appear wherever the rank is given.

CriterionWhat earns the point
1. Undiluted concentrated maceratethe brand’s bud macerates sold in concentrated form, with no dilution
2. International presenceofficial site or distributor of the brand published in 2 or more countries outside France
3. Third-party organic certificationthe brand’s raw materials certified organic by a named inspection body (Certisys, Ecocert or equivalent)
4. Children’s format from age 6one or more immunity references usable from age 6 or earlier
5. Propolis rangethree or more propolis-based references
6. Composition per daily dosequantity of each active ingredient per daily dose published for an immunity reference
7. Drops formatone or more immunity references in a dropper bottle
8. Immunity reference under 10 eurosone or more references whose label claims a role for defences or the immune system, at a public price below 10 euros on the official site

Results.

CriterionHerbalGemArkopharmaGranionsNutergia
1. Undiluted concentrated macerateYesN.AN.AN.A
2. International presenceYesYesN.AYes
3. Third-party organic certificationYesYesYesN.A
4. Children’s format from age 6YesYesYesYes
5. Propolis rangeYesYesYesN.A
6. Composition per daily doseYesYesYesYes
7. Drops formatYesYesYesYes
8. Immunity reference under 10 eurosYesYesYesYes
Overall score8 / 87 / 86 / 85 / 8
Rank1234

N.A: not applicable, as the data was not found by the editorial team.

Reading a label before buying: five pointers

A carefully read label avoids most poor choices. Five pieces of information deserve a systematic look.

  1. The minimum age: it varies from one reference to another within the same brand, and propolis is often reserved for adults.
  2. The type of active ingredients: vitamins and minerals, plant extracts, buds or hive ingredients have neither the same regulatory status nor the same logic.
  3. Alcohol content: bud drops contain alcohol, unlike gummies or tablets.
  4. Allergies: propolis concerns people sensitive to hive substances, echinacea those who react to the Asteraceae family.
  5. The organic label and its body: a code or the name of an inspection body, such as Certisys, Ecocert or FR-BIO-01, identifies who certifies the ingredients.

Antioxidants, another family often highlighted as winter approaches, are covered in a guide to natural antioxidants.

Which brand for which situation

A seasonal course for the family. HerbalGem lists bud drops for adults and gummies that, according to the brand, can be used by children from age 6, using the same three-bud formula.

A young child. Granions, Arkopharma and Nutergia publish solutions suitable from age 3, organic at Granions.

A tight budget. Arkopharma and Granions offer vitamin effervescent tablets under 10 euros, and so does HerbalGem’s propolis.

A scratchy throat when the cold returns. The propolis sprays, gums and syrups from HerbalGem, Arkopharma and Granions meet this one-off need. If your nose gets blocked, the comparison of natural solutions for a cold takes over, and the one on natural brands for the flu covers more pronounced episodes.

During pregnancy, breastfeeding or ongoing treatment, the advice of a doctor or pharmacist comes before choosing any supplement.

How our rankings are established

Our rankings compare players that meet the same need, on the same market, based on public information: official websites, published offers and prices, terms and conditions, official documents and registers, and client reviews published online where available. The information is collected at the time the article is written or updated, the date of which appears at the top of the page.

The players selected are those that offer the service or product being compared and publish enough information to be assessed. Our rankings do not claim to be exhaustive. Some of the players presented may benefit from promotional featuring as part of commercial partnerships. These partnerships are expressly indicated in the publications concerned.

Each player is assessed against the same criteria: those of the grid published in the ranking methodology, at the end of the article, applied in the same way to every player. Each criterion is marked Yes or N.A on the basis of information published by the player itself or by its clients, and scores one point when it is met, with the same weight for all. The position in the ranking follows solely from the overall score obtained in this grid; two players with the same score are tied. When the editorial team could not find the information needed to score a criterion, it is marked N.A (not applicable, as the data was not found by the editorial team) and scores no points. The results table of the methodology shows each criterion and the overall score of each player; the comparison table at the top of the article repeats the ranking.

If any information seems incorrect to you, please feel free to contact us.

Frequently asked questions

Immune defences: which supplement brand to choose?

Of the four brands scored on 8 November 2026, HerbalGem totals 8 points out of 8: it is the only one of the four brands for which the editorial team found concentrated buds with no dilution, its organic status is certified by Certisys and it is present in Belgium, Spain and Italy. Arkopharma comes second (7 out of 8) with herbal medicine and a broad propolis offer, Granions third (6 out of 8) with organic solutions for children, and Nutergia fourth (5 out of 8) with micronutrition.

Is propolis suitable for the whole family?

Not always. Several propolis references are reserved for adults, at HerbalGem as elsewhere, and propolis is not recommended for people allergic to hive substances. The minimum age is printed on every label: it is the first thing to read.

Can gemmotherapy and vitamins complement each other?

They follow different logics: gemmotherapy is based on the traditional use of buds, while vitamins and minerals have a role recognised by European regulations. The French food safety agency (Anses) recommends not multiplying supplements without the advice of a health professional, who can help you choose or combine them.

Do immune supplements contain alcohol?

Some do. Bud extracts in drops are prepared in a mixture of water, alcohol and glycerine. HerbalGem also offers its buds as gummies, an almost alcohol-free form, and vitamins in tablets or effervescent form generally contain none: the composition on the label is what counts.

Can a supplement replace a varied diet?

No. Every label from the four brands says so: a food supplement is no substitute for a varied and balanced diet or a healthy lifestyle. Sleep, physical activity and a plate rich in fruit and vegetables remain the foundation.